Hydrocodone vs Oxycodone: What’s the Difference?

Buy Hydrocodone and Oxycodone are prescribed painkillers that belong to the opioid pain relief drugs. They are prescribed to treat moderate or severe pain, including acute pain following chemotherapy or cancer-related pain. Read on to discover the many similarities and distinctions between hydrocodone and Oxycodone.

What are the commonalities between hydrocodone and Oxycodone?


Both are semi-synthetic opioids that are narcotic painkillers composed of morphine that have been produced in a lab. Both of these medications are utilized to treat severe pain in combination with non-narcotic pain medication like acetaminophen (Tylenol) and Ibuprofen (Advil, Motrin). These prescription medications are usually used to provide short-term relief from pain. For instance, hydrocodone and oxycodone prescriptions are typically used to treat pain following major surgery or injury like a fracture. Opioids such as hydrocodone and Oxycodone can also be employed to treat extreme pain due to advanced cancer. These and other opiates are prescribed to treat chronic, severe pain for people suffering from impaired kidney function that are not suitable candidates for NSAIDs or nerve pain medications such as gabapentin.


Both are available in generic lower-cost versions, as well as brand name versions. They can be used as a stand-alone product or with non-narcotic pain medication like acetaminophen, aspirin, and Ibuprofen. Dosage options for Oxycodone and hydrocodone are immediate-release and extended-release tablets, capsules, and liquid solutions. The immediate-release varieties are consumed every 4-6 hours. While the extended-release ones are consumed every 12 hours to relieve pain.


Both Oxycodone as well as hydrocodone have an identical method of action. These two substances relieve pain by binding to opioid receptors within the brain’s central nervous system and blocking pain signals. Hydrocodone, as well as Oxycodone, act on the reward system of the brain and alter how you experience pain.


Studies have demonstrated that Buy Oxycodone Online and hydrocodone work equally well to relieve temporary pain.


Specific side effects of Oxycodone and hydrocodone are similar, including nausea, constipation, dry mouth, sleepiness, and headache.


Another commonality between Oxycodone and hydrocodone is that abruptly stopping both drugs could cause withdrawal symptoms for opioid users.


Hydrocodone and Oxycodone are both utilized to treat minor to moderate pain. They aren’t the most preferred option for treating chronic or prolonged pain since they’re quick-acting and can become very addictive and habit-forming.”

It’s, therefore, reserved for patients suffering from chronic pain who cannot tolerate other forms of pain medications.

Hydrocodone and Oxycodone have been classed as Schedule II drugs because of their risk of physical and mental dependence that can lead to addiction and abuse. Hydrocodone and oxycodone abuse is associated with a significant likelihood of developing drug-seeking behavior and an opioid dependence disorder. Opioid addiction can cause serious health problems, including overdoses and even death.


Hydrocodone and oxycodone use can increase the chance of life-threatening respiratory depression, a condition that causes breathing difficulties, which causes your breath to become extremely shallow. It could lead to death if left untreated. This risk is higher when taking other medicines with similar effects or if you suffer from an underlying lung disease.

Other severe but rare adverse reactions of Oxycodone and hydrocodone can include chest pain, hallucinations, confusion, agitation; rapid or slow heartbeats, muscle tension, twitching muscles; nausea, vomiting, shivering; diarrhea; loss of appetite, and weakness; dizziness, diminished sexual desire, irregular menstrual cycle as well as allergic reactions that result in swelling of the face, eyes mouth, lips, or throat, a skin rash that causes itching, hives, and trouble swallowing or breathing.

Utilizing these two medicines along with other medications from the opioid class isn’t uninvolved during pregnancy and could result in congenital disabilities. Opioid medications should not be used to manage pain when breastfeeding since they could infiltrate the milk of the mother and harm the baby.

What are the significant differences between hydrocodone versus Oxycodone?

Here are a few distinctions between hydrocodone and Oxycodone:

Oxycodone is more potent than hydrocodone on a milligram-to-milligram basis. But both drugs provide the same level of pain relief.

Hydrocodone can cause constipation, fatigue and urinary problems, muscle tightening, and sleep issues as possible side effects. It tends to trigger adverse effects like flushing and mood fluctuations. But, every person’s experience with a particular medication may be different. There are times when you can tolerate one medication, such as hydrocodone or Oxycodone, more than the other, with fewer adverse negative effects.

The half-life for Oxycodone is 2.6 hours. The time-to-use of hydrocodone will be 4.2 hours. Half-life refers to the length of time it takes the body to remove only half of the amount initially absorbed by the drug. Since hydrocodone remains longer in your system and is more potent, it has a more significant potential for addiction and abuse. But Oxycodone and hydrocodone fall under Schedule II drugs that carry the possibility of addiction.

Be aware that this information about drugs does not constitute a substitute for the advice of a medical professional. If you have any further questions or would like to know what is the best choice for you, oxycodone vs. hydrocodone, talk to your doctor or pharmacist.

Frequently Asked Questions


Opioids like morphine, hydrocodone, oxycodone codeine, tramadol, and fentanyl are among the most potent pain relievers available to treat acute and chronic pain. Fentanyl is an artificial opioid that is between 50 and 100 times more powerful than morphine, which is an organic opioid. This makes Fentanyl one of the most potent painkillers. It’s used to treat extreme pain, including pain caused by advanced cancer.


A double-masked, controlled, randomized study found that Oxycodone was roughly 1.5 times more powerful than hydrocodone. However, both medications provide adequate pain relief.


It is not a controlled substance in class IV. A small, double-masked, random study found that Oxycodone is eight times more potent than tramadol.WHAT’S THE DIFFERENCE BETWEEN OXYCONTIN AND OXYCODONE?The Oxycodone brand is a generic drug. OxyContin is a brand-name product that has Oxycodone as its active ingredient. OxyContin is a controlled-release formula that gives continuous, 24-hour relief from pain.

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